Monitoring the physiological status of a large free-swimming great whale is extremely difficult. Exhaled breath condensate (EBC), the whales’ ‘blow’, could be a non-invasively collected matrix to be used to evaluate the physiological status of cetaceans.  We believe that this offers enormous promise, as the ‘blow’ as an organic matrix composed of lipids, proteins and cells derived from the respiratory tract, has proven an extremely useful to detect hormones, DNA and a variety of microorganism.